All of a sudden none of the users on my cpanel boxes can send e-mail using their mail clients via SMTP. No problems receiving, but no go on the outgoing mail. Everything works just fine using the webmail. No changes have been done on the server lately, except for the automated cpanel updates. CFS installed and set up to allow connections on port 25. Just to make sure this was not a firewall issue, the firewall was disabled and no difference.
Looks like the connection can not be made properly, as no new entires show up in /var/log/maillog when I try sending.
Need some help solving this one and a couple of ideas on where I should start to look.
Edit to add: No, my ISP does not block port 25



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