Hello, first time I have come across this problem.
I just setup a VPS and install the latest cPanel on it (WHM 11.32.3 (build 21)).
I went through easyapache as usual, chose Apache 2.2.22 & php 5.3.13 along with some extensions, pdo and pdo_mysql.
When the easyapache finishes I cannot choose a handler, it just says 'none'. Anyway, I save the config, open up php.ini and disable extension=pdo.so. Everything works then, I can choose a handler and apache works fine.
Any idea why this is happening?