You can either make the file mutable or you can instead exclude the file. If you make the file mutable, you would issue:
If you exclude the file, it would be:
chattr -ia /usr/local/cpanel/bin/startmelange
You would not have to do both. Doing one will preclude the other triggering the alert.
echo "/usr/local/cpanel/bin/startmelange" >> /etc/cpanelsync.exclude
As for /scripts/upcp --sync, this simply runs a cPanel update and syncs the files. It's the same as running a forced cPanel update. It will change components in cPanel because it updates everything to the latest versions for your tier.