others being hosted on my domain...

[spike326]

with WebHost Manager/Cpanel can I setup hosting packages where someone, say spike, has hosting on my domain (ie mydomain.com) so spike's website would be http://spike.mydomain.com? If so how can I do this so that spike has his own secure ftp access outside of my domain, mydomain.com?

[linux-image]

you can make a sub-domain for spike. then create an ftp user for the folder spike inside the public_html folder. But your idea of making spike access somewhere outside your domain is impossible.

[LA_fro]

Actually you can create an account in WHM that uses sub.domain.com as its domain.