InnoDB

Is there any cons of enabling InnoDB? If not, how do I enable this?

My current /etc/my.cnf

[mysqld]
datadir=/var/lib/mysql
skip-locking
skip-innodb
max_connections = 750
key_buffer = 128M
myisam_sort_buffer_size = 64M
join_buffer_size = 1M
read_buffer_size = 1M
sort_buffer_size = 2M
table_cache = 1800
thread_cache_size = 128
wait_timeout = 1200
connect_timeout = 10
tmp_table_size = 128M
read_rnd_buffer_size = 524288
bulk_insert_buffer_size = 8M
max_allowed_packet = 16M
max_connect_errors = 10
query_cache_limit = 2M
query_cache_size = 128M
query_cache_type = 1
query_prealloc_size = 16384
query_alloc_block_size = 16384
old-passwords

[mysql.server]
user=mysql
basedir=/var/lib

[mysqld_safe]
err-log=/var/log/mysqld.log
pid-file=/var/lib/mysql/mysql.pid
open_files_limit=8192

[mysqldump]
quick
max_allowed_packet=16M
default-character-set=binary

[mysql]
no-auto-rehash
#safe-updates

[isamchk]
key_buffer=64M
sort_buffer=64M
read_buffer=16M
write_buffer=16M

[myisamchk]
key_buffer=64M
sort_buffer=64M
read_buffer=16M
write_buffer=16M

[mysqlhotcopy]
interactive-timeout