Typically mail.domain.com will route to the main page served up on the IP of mail.domain.com
For example, if foodom.com was the main page that was returned when going to 123.456.78.91 and mail.somedom.com also pointed to 123.456.78.91, you would be able to determine that foodom.com was the actual site that was compromised.
Once you determine which site is compromised it is best to get a stat of the index file so you know when the defacement occurred and then you can backtrack through the logs to see how the malicious user compromised your account.