I am running cPanel on OpenSuSE 10.2 with no problems.
I have found the only requirement is to change the contents of /etc/SuSE-release to report version 10.0
OpenSuSE is not supported by cPanel, but I have not had any issues anyone with some linux experience could not resolve. The best advise I can give is to keep your distribution installation to the bare minimum. Only install what you need, since cPanel installs all the packages it needs to function.