With the exception of the SARE ruleset, I think the documentation is very good. Although my Exim settings are little different. I reject during SMTP for any spam with a score over 10.0, and I use Zen and the Barracuda RBL as DNSBLs for rejection during SMTP. I don't accept-bounce anything.
Of course, if you're clientele aren't predominantly in the US and|or your server isn't in the US, you probably need to be careful about what RBLs you use since some may list more foreign IP space.
Plus I usually copy the system filter over to a new filename and reference that new filename. And in the new filter file I remove the eml blocking.
Of course, I think out of all of them Pyzor is less effective. I even saw recommendations on one site [I dont have the link] where they suggested Pyzor was basically useless unless a very small patch was applied to it. I didn't apply the path. The version of Pyzor I have is from 2011, and I think the post I saw was earlier than that. So I'm assuming that the version available on Sourceforge is the best version and that it doesn't need any patch to be as effective as it can be.